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The enormous, automatic spending cuts known as "sequestration" went into effect on Friday. Guest host Celeste Headlee talks to NPR's Mara Liasson about the politics of the spending cuts and to NPR's Tamara Keith about what to expect in the coming weeks. We also hear from some people across America about how they will or will not be affected by the loss of government money and possible furloughs of federal workers.

NPR's latest survey finds the contact tracing workforce now tops 70,000, a dramatic increase in the last two months. But to truly meet the growing demand, new federal funding will be key.

Atlanticwriter Ed Yong says the COVID vaccination program will be the most complicated the U.S. has ever attempted: "It's going to be a slow process, and there are a lot of possible roadblocks."

Compared to last spring, there's more clinical knowledge about how to treat COVID-19, and bigger stockpiles of protective equipment. But nurses worry about staffing shortages as patient numbers grow.

The new book Fulfillment, by Alec MacGillis, looks at America's economic history — as well as its future — through the lens of Amazon.

After her son's death, a mother in the Midwest promotes mental health for environmentalists. It's part of a larger push to address the burnout and psychological stress that can affect activists.

Water washed over parts of Manhattan on Monday night, like heavy seas coming over the deck of a ship. Meanwhile, the eye of the storm came ashore in New Jersey. Steve Inskeep and Renee Montagne speak with Jeff Brady in New Jersey, Jon Hamilton in Washington and Robert Smith in New York for a look at the damage and what's to come.

President Trump is expected to make remarks Thursday on the opioid crisis. The House is slated to vote on the Senate's budget resolution, which is key for any movement on a tax bill.

Corker told The New York Times that Trump is putting the nation on a path to WW III Hollywood mogul Harvey Weinstein has been fired as head of the Weinstein Company over sexual harassment allegations.

Both the Trump and Biden campaigns are competing for voters in key swing states like Pennsylvania. But is either of the major parties trying to engage Black voters in cities like Pittsburgh?